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Graham Coop

Updated perspective piece on why human genetics should move away from using "genetic ancestry" groups as a sample description.

arxiv.org/abs/2207.11595

arXiv.orgGenetic similarity versus genetic ancestry groups as sample descriptors in human geneticsA common sample descriptor in human genomics studies is that of 'genetic ancestry group', with terms such as 'European genetic ancestry' or 'East Asian genetic ancestry' frequently used in publications to describe the genetics of groups of individuals based on the analysis of their genotypes. In this Perspective, I argue that these terms are imprecise and potentially misleading and that, for most applications, simple statements of genetic similarity represent a more accurate description.
Jan 10, 2023, 03:50 AM·Public·Web
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Mwinyele

@gcbias
Some #FoodForThought from the #researchpaper linked above💡💡💡

“Importantly, in my view, the term ‘genetically similar to’ also helps to avoid the assumption of homogeneity within labels; ‘similar to’ does not imply ‘same as’. Similarity-based sample descriptors also move us some way to acknowledging the continuous nature of #geneticvariation across #humangroups in our sample descriptions. I am more genetically similar to some samples than I am to others, but that does not imply that there are natural groupings. Nor do similarity-based labels imply how I, as an individual, might choose to identify or what distribution of environments I might experience. For example, a person may be genetically similar to 1000 #Genomes samples labeled Southern Asian, yet in itself this similarity does not identify them as Southern Asian, whereas stating that a person has ‘Southern Asian #geneticancestry ’ comes much closer to making that linkage in people’s minds.
Working out the #genealogicalhistory of individuals and of groups of people from around the world is a fascinating area of research, but it should not be the day job of the majority of researchers in the field of #humangenetics , who instead need accurate sample descriptors of current day #geneticdiversity that aid clear communication.”
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Adding colour to #discourse with this screenshot attachment and link. Extraordinary future ahead in the field of human genetics and #humanidentity, in general. #TheLancet #AmbroiseWonkam #johnhopkinsuniversity #schoolofmedicine #geneticvariation #geneticmedicine #MckusickNathansInstituteofGeneticMedicine

thelancet.com/pdfs/journals/la

doi.org/10.1016/S0140-6736(22)

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#SarsCoV2 #researchgate
#geneticdata #geneticdisease #ethnicity #populationdescriptors #racialmakeup #racialclassification #ethnicclassification #nationalacademiesofsciencesengineeringand #biomedicalresearch #rx #med #ethnicorigins #dei #biodiversity #bloodbank #organdonor #geneticlandscapes #socialdeterminantsofhealth #clinicalgenetics #therapeutics #diagnostics #treatments #ancientdna #genealogy #nondarwinian #demography #demographics #polygenics #nationalinstitutesofhealth #nih #medicine #geneticancestor #humangenetics #biomedicine #biomed #racialidentity #ancestralidentity #culturalidentity #crt #criticalracetheory #anthropology #biobank #23andme #familytree #familyheritage #ancestralheritage #commonancestor #biomedical #populationbiology #geobiologie #geobiology #geneticmapping #blooddonor #blooddonation #populationhealth #admixedancestry #phenotype #phenotypingdata #phenotypedata #americanjournalofhumangenetics

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