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A great first step in developing a #LassaFever vaccine for human use. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00048-X/fulltext#%20
First time in human trial, assessing safety and tolerability of a vaccine. Long way to go to get it into the arms of people who need it most.
The LancetImmunogenicity, safety, and tolerability of a recombinant measles-vectored Lassa fever vaccine: a randomised, placebo-controlled, first-in-human trialMV-LASV showed an acceptable safety and tolerability profile, and immunogenicity seemed
to be unaffected by pre-existing immunity against the vector. MV-LASV is therefore
a promising candidate for further development.