In 2019, Emily Josephs (@Emjo), Nancy Chen and I proposed a Special Issue of Proceedings B on "#Wild #Quantitative #Genomics
After a marathon few years, we are delighted to present 13 cutting-edge papers on QGen.
Buckle in: 1/16
https://royalsocietypublishing.org/topic/special-collections/wild-quantitative-genomics
Do you need a primer on quantitative genetics and genomics in the wild? Start with our Editorial on the history, current state, and the likely future of the field. 2/16
https://royalsocietypublishing.org/doi/10.1098/rspb.2022.1930
First, genomics helps to understand genetic architecture & selection on Q traits. Laura Duntsch et al showed SNPs can replace pedigrees to estimate heritability, and that morphological traits in Hihi (stitchbird) are polygenic. 3/16
https://royalsocietypublishing.org/doi/full/10.1098/rspb.2020.0948
Ya-Ping Lin et al identified quantitative trait loci for traits directly related to fecundity in Boechera stricta, and show that they play a role in local adaptation. 4/16
https://royalsocietypublishing.org/doi/10.1098/rspb.2020.2472
Similarly, a study led by @jenncoughlan identified quantitative trait loci for locally-adapted life-history traits in Mimulus, with some correlated traits sharing major effect loci. 5/16
https://royalsocietypublishing.org/doi/10.1098/rspb.2021.0077
Lukas Tietgen and authors use GWAS to identify MC1R as a large effect locus on fur colour in the Arctic fox, and that genotype can influence survival 6/16
https://royalsocietypublishing.org/doi/10.1098/rspb.2021.1452
A review by Arild Husby considers the potential contribution of epigenetics to trait variation and what methods and questions we will be using and asking in the near future. 7/16
https://royalsocietypublishing.org/doi/10.1098/rspb.2021.1633
Second, investigating evolutionary change across the genome is getting easier. Genomic prediction is opening new research avenues for conservation and microevolution, as reviewed by
Suzanne McGaugh et al. 8/16
https://royalsocietypublishing.org/doi/10.1098/rspb.2021.0693
Darren Hunter, Jon Slate et al use genomic prediction to show cryptic microevolution of breeding values for body weight in Soay sheep. 9/16
https://royalsocietypublishing.org/doi/10.1098/rspb.2022.0330
John Kelly reviews the use of selection component analyses to estimate selection by relating individual genotypes to fitness components, using simulations and empirical data. 10/16
https://royalsocietypublishing.org/doi/10.1098/rspb.2021.1812
And @Amandastahlke et al integrate a population genetics approach to investigate evolution in six populations of Tasmanian Devils in the face of transmissible cancer. 11/16
https://royalsocietypublishing.org/doi/10.1098/rspb.2021.0577
Third, multivariate quantitative genetics is moving beyond the geno-pheno map. Leslie Kollar et al examine the genetic architecture of sexual antagonism in Ceratodon moss. 12/16
https://royalsocietypublishing.org/doi/10.1098/rspb.2020.2908
A study by Addam Reddiex and Steve Chenoweth conducted a multivariate GWAS with G matrix and selection estimation to examine constraints on sexual selection in D. serrata 13/16
https://royalsocietypublishing.org/doi/full/10.1098/rspb.2021.1785
Finally, whose trait is it anyway?
Anna O'Brien and authors present a compelling simulation study of a host–microbe mutualism to explore the evolution of a multi-genomic quantitative trait. 14/16
https://royalsocietypublishing.org/doi/10.1098/rspb.2020.2483
This special issue was compiled during the Covid-19 pandemic, and we are so grateful for the mammoth effort of the authors, reviewers, @royalsociety@bird.makeup publishing staff & Gary Carvalho, who was a fantastic senior editor 15/16
And last of all, no thanks to the two new babies and puppy that arrived in our households during the whole editorial process!
~fin/end~
https://royalsocietypublishing.org/doi/10.1098/rspb.2022.1930